Reactome | Active PLC-gamma1 dissociates from EGFR

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Active PLC-gamma1 dissociates from EGFR Show undefined attributes

category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10667597
displayName	Active PLC-gamma1 dissociates from EGFR
eventOf	[Pathway:R-XTR-212718] EGFR interacts with phospholipase C-gamma - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-212713] Active PLC-gamma1 dissociates from EGFR - Homo sapiens
input	[Complex:R-XTR-212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Active PLC-gamma1 dissociates from EGFR
output	[Complex:R-XTR-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-XTR-167679] phospho-plcg1 [plasma membrane]
precedingEvent	[Reaction:R-XTR-212710] EGFR activates PLC-gamma1 by phosphorylation - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-212713
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-212718] EGFR interacts with phospholipase C-gamma
(inferredTo)	[Reaction:R-HSA-212713] Active PLC-gamma1 dissociates from EGFR

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