Reactome | definitive endoderm cell

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definitive endoderm cell Show undefined attributes

cellType	[CellType:9907635] endodermal cell
consumedByEvent	[CellDevelopmentStep:R-HSA-9911210] Definitive endoderm cell produces dorsal foregut endoderm cell - Homo sapiens [CellDevelopmentStep:R-HSA-9911214] Definitive endoderm cell produces ventral foregut endoderm cell - Homo sapiens
created	[InstanceEdit:9911209] Orlic-Milacic, Marija, 2024-05-27
dbId	9911207
displayName	definitive endoderm cell
inDisease	false
markerReference	[MarkerReference:9921367] SOX17 [nucleoplasm] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921110] CER1 [exocytic vesicle] Secreted cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells [MarkerReference:9927540] GATA6 [nucleoplasm] GATA6 is essential for endoderm formation from human pluripotent stem cells [MarkerReference:9921105] FOXA2 [nucleoplasm] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921361] SOX17 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921104] CXCR4 [plasma membrane] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921438] MIXL1 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921404] FOXA3 mRNA [cytosol] Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells [MarkerReference:9921436] OTX2 mRNA [cytosol] Distinct gene expression signatures in human embryonic stem cells differentiated towards definitive endoderm at single-cell level [MarkerReference:9921146] FOXA2 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921434] HHEX mRNA [cytosol] Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction [MarkerReference:9921432] LEFTY1 mRNA [cytosol] Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development [MarkerReference:9921127] CER1 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921351] GATA6 mRNA [cytosol] Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells [MarkerReference:9921350] GATA4 mRNA [cytosol] Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells [MarkerReference:9921377] HNF4A mRNA [cytosol] Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells [MarkerReference:9921134] CXCR4 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921357] GATA4 [nucleoplasm] Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells [MarkerReference:9921420] GSC mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm
maxDepth	2
modified	[InstanceEdit:9928160] Orlic-Milacic, Marija, 2024-11-11
name	definitive endoderm cell
proteinMarker	[EntityWithAccessionedSequence:R-HSA-9921118] CER1 [exocytic vesicle] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2980772] CXCR4 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-211275] FOXA2 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-400553] GATA4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-452902] GATA6 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5625834] SOX17 [nucleoplasm] - Homo sapiens
rNAMarker	[EntityWithAccessionedSequence:R-HSA-9921130] CER1 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921116] CXCR4 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921122] FOXA2 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921400] FOXA3 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921346] GATA4 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921354] GATA6 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921422] GSC mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9915042] HHEX mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921379] HNF4A mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921439] LEFTY1 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921435] MIXL1 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921433] OTX2 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9921364] SOX17 mRNA [cytosol] - Homo sapiens
schemaClass	Cell
species	[Species:48887] Homo sapiens
stId	R-HSA-9911207
tissue	[Anatomy:9928158] endoderm

Referrals

(input)

[CellDevelopmentStep:R-HSA-9911210] Definitive endoderm cell produces dorsal foregut endoderm cell
[CellDevelopmentStep:R-HSA-9911214] Definitive endoderm cell produces ventral foregut endoderm cell

(cell)

[MarkerReference:9921367] SOX17 [nucleoplasm] Efficient differentiation of human embryonic stem cells to definitive endoderm
[MarkerReference:9921110] CER1 [exocytic vesicle] Secreted cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells
[MarkerReference:9927540] GATA6 [nucleoplasm] GATA6 is essential for endoderm formation from human pluripotent stem cells
[MarkerReference:9921105] FOXA2 [nucleoplasm] Efficient differentiation of human embryonic stem cells to definitive endoderm
[MarkerReference:9921361] SOX17 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm
[MarkerReference:9921104] CXCR4 [plasma membrane] Efficient differentiation of human embryonic stem cells to definitive endoderm
[MarkerReference:9921438] MIXL1 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm
[MarkerReference:9921404] FOXA3 mRNA [cytosol] Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells
[MarkerReference:9921436] OTX2 mRNA [cytosol] Distinct gene expression signatures in human embryonic stem cells differentiated towards definitive endoderm at single-cell level
[MarkerReference:9921146] FOXA2 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm
[MarkerReference:9921434] HHEX mRNA [cytosol] Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction
[MarkerReference:9921432] LEFTY1 mRNA [cytosol] Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development
[MarkerReference:9921127] CER1 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm
[MarkerReference:9921351] GATA6 mRNA [cytosol] Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells
[MarkerReference:9921350] GATA4 mRNA [cytosol] Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells
[MarkerReference:9921377] HNF4A mRNA [cytosol] Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells
[MarkerReference:9921134] CXCR4 mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm
[MarkerReference:9921357] GATA4 [nucleoplasm] Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells
[MarkerReference:9921420] GSC mRNA [cytosol] Efficient differentiation of human embryonic stem cells to definitive endoderm

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