UniProt:Q9Y261 FOXA2

chain
  • chain:1-457
checksum 61DDE4C75C70680A
comment
  • FUNCTION Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.SUBUNIT Binds DNA as a monomer. Binds TLE1 (By similarity). Interacts with FOXA1 and FOXA3 (PubMed:19919681). Interacts with PRKDC (PubMed:19478084). Interacts with AKT1 (By similarity). Interacts with TET1; this interaction may recruit TET1 to specific genomic loci to mediate their demethylation (PubMed:35798741).SUBCELLULAR LOCATION Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.ALTERNATIVE PRODUCTS Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION Hepatocyte nuclear factors entry
crossReference
databaseName UniProt
dbId 56610
description
  • recommendedName: Hepatocyte nuclear factor 3-beta shortName: HNF-3-beta shortName: HNF-3B alternativeName: Forkhead box protein A2 alternativeName: Transcription factor 3B shortName: TCF-3B
displayName UniProt:Q9Y261 FOXA2
geneName
  • FOXA2
  • HNF3B
  • TCF3B
identifier Q9Y261
isSequenceChanged false
keyword
  • 3D-structure
  • Activator
  • Alternative splicing
  • Chromatin regulator
  • Cytoplasm
  • Developmental protein
  • DNA-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • FOXA2
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FOXA2_HUMAN
  • Q8WUW4
  • Q96DF7
sequenceLength 457
species [Species:48887] Homo sapiens
stId uniprot:Q9Y261
url http://purl.uniprot.org/uniprot/Q9Y261
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