Reactome | CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D

CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D

Stable Identifier

R-HSA-209868

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

ReviewStatus

5/5

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CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D

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The second step in vitamin D activation requires hydroxylation of 25-hydroxyvitamin D (calcidiol, 25(OH)D) to 1-alpha, 25-dihydroxyvitamin D (1,25(OH)2D). This conversion is mediated by 25-hydroxyvitamin D-1-alpha hydroxylase (CYP27B1), an outer mitochondrial membrane-resident protein (Zehnder et al. 2002, Fritsche et al. 2003, Sawada et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
11856765	Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion Zehnder, D, Stewart, PM, Howie, AJ, Bland, R, Wheeler, DC, Hewison, M, Williams, MC, Chana, RS	J Am Soc Nephrol	2002
12855575	Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells Kreutz, M, Andreesen, R, Mondal, K, Fritsche, J, Ehrnsperger, A	Blood	2003
10518789	Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli Kato, S, Sakaki, T, Sawada, N, Inouye, K, Takeyama, K, Kitanaka, S	Eur. J. Biochem.	1999