Reactome | CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D

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CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D Show undefined attributes

catalystActivity	[CatalystActivity:10577233] calcidiol 1-monooxygenase activity of CYP27B1(?-508) [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10577235
displayName	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
eventOf	[Pathway:R-DRE-211916] Vitamins - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - Danio rerio
inferredFrom	[Reaction:R-HSA-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Homo sapiens
input	[SimpleEntity:R-ALL-209804] 25(OH)D [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
output	[SimpleEntity:R-ALL-209800] 1,25(OH)2D [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-DRE-209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - Danio rerio
regulatedBy	[NegativeRegulation:9692889] Negative regulation by 'Fru [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-209868
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-211916] Vitamins [Pathway:R-DRE-196791] Vitamin D (calciferol) metabolism
(precedingEvent)	[Reaction:R-DRE-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(inferredTo)	[Reaction:R-HSA-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D

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