Reactome | NAGLU hydrolyses heparan chain(2)

Schema > Reaction > Entries

NAGLU hydrolyses heparan chain(2) Show undefined attributes

authored	[InstanceEdit:2090024] Jassal, B, 2012-02-06
catalystActivity	[CatalystActivity:1678739] alpha-N-acetylglucosaminidase activity of NAGLU(59-743) [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:2090024] Jassal, B, 2012-02-06
dbId	2090038
diseaseReaction	[FailedReaction:R-HSA-9036052] Defective NAGLU does not hydrolyse heparan chain(2) - Homo sapiens
displayName	NAGLU hydrolyses heparan chain(2)
edited	[InstanceEdit:2090024] Jassal, B, 2012-02-06
eventOf	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-1678854] GUSB tetramer hydrolyses CS/HS precursor - Homo sapiens
input	[SimpleEntity:R-ALL-2090053] GlcNAc- group [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1678725] Cloning and expression of the gene involved in Sanfilippo B syndrome (mucopolysaccharidosis III B) [LiteratureReference:1678779] Molecular defects in Sanfilippo syndrome type B (mucopolysaccharidosis IIIB)
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	NAGLU hydrolyses heparan chain(2)
orthologousEvent	[Reaction:R-BTA-2090038] NAGLU hydrolyses heparan chain(2) - Bos taurus [Reaction:R-DDI-2090038] NAGLU hydrolyses heparan chain(2) - Dictyostelium discoideum [Reaction:R-CEL-2090038] NAGLU hydrolyses heparan chain(2) - Caenorhabditis elegans [Reaction:R-DME-2090038] NAGLU hydrolyses heparan chain(2) - Drosophila melanogaster [Reaction:R-GGA-2090038] NAGLU hydrolyses heparan chain(2) - Gallus gallus [Reaction:R-DRE-2090038] NAGLU hydrolyses heparan chain(2) - Danio rerio [Reaction:R-SSC-2090038] NAGLU hydrolyses heparan chain(2) - Sus scrofa [Reaction:R-CFA-2090038] NAGLU hydrolyses heparan chain(2) - Canis familiaris [Reaction:R-RNO-2090038] NAGLU hydrolyses heparan chain(2) - Rattus norvegicus [Reaction:R-MMU-2090038] NAGLU hydrolyses heparan chain(2) - Mus musculus
output	[SimpleEntity:R-ALL-9941448] -R [lysosomal lumen] [SimpleEntity:R-ALL-1678743] GlcNAc [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-2090085] HGSNAT oligomer acetylates Heparan chain(1) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2090038
summation	[Summation:2457614] Alpha-N-acetylglucosaminidase (NAGLU) also hydrolyses anothe...
updateTrackers	[UpdateTracker:9788351] Update Tracker - [Reaction:2090038] NAGLU hydrolyses heparan chain(2) - v42:[add_removeSummation] [UpdateTracker:9953588] Update Tracker - [Reaction:2090038] NAGLU hydrolyses heparan chain(2) - v93:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9788351] Update Tracker - [Reaction:2090038] NAGLU hydrolyses heparan chain(2) - v42:[add_removeSummation] [UpdateTracker:9953588] Update Tracker - [Reaction:2090038] NAGLU hydrolyses heparan chain(2) - v93:[add_removeOutput]
(normalReaction)	[FailedReaction:R-HSA-9036052] Defective NAGLU does not hydrolyse heparan chain(2)
(hasEvent)	[Pathway:R-HSA-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-HSA-1678854] GUSB tetramer hydrolyses CS/HS precursor