Reactome | GUSB tetramer hydrolyses CS/HS precursor

Schema > Reaction > Entries

GUSB tetramer hydrolyses CS/HS precursor Show undefined attributes

authored	[InstanceEdit:1678853] Jassal, B, 2011-10-19
catalystActivity	[CatalystActivity:1678848] beta-glucuronidase activity of GUSB tetramer [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1678853] Jassal, B, 2011-10-19
crossReference	[DatabaseIdentifier:9941157] RHEA:17634
dbId	1678854
diseaseReaction	[FailedReaction:R-HSA-9036070] Defective GUSB does not hydrolyse CS/HS precursor - Homo sapiens
displayName	GUSB tetramer hydrolyses CS/HS precursor
edited	[InstanceEdit:1678853] Jassal, B, 2011-10-19
eventOf	[Pathway:R-HSA-2024101] CS/DS degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-2090079] GLB1 hydrolyses linker chain(2) - Homo sapiens
input	[SimpleEntity:R-ALL-2065212] CS/HS precursor [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1678862] Cloning, sequencing, and expression of cDNA for human beta-glucuronidase [LiteratureReference:1678847] A novel inhibitor of beta-glucuronidase: L-aspartic acid [LiteratureReference:1793200] Mutations and polymorphisms in GUSB gene in mucopolysaccharidosis VII (Sly Syndrome)
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GUSB tetramer hydrolyses CS/HS precursor
orthologousEvent	[Reaction:R-BTA-1678854] GUSB tetramer hydrolyses CS/HS precursor - Bos taurus [Reaction:R-CEL-1678854] GUSB tetramer hydrolyses CS/HS precursor - Caenorhabditis elegans [Reaction:R-DME-1678854] GUSB tetramer hydrolyses CS/HS precursor - Drosophila melanogaster [Reaction:R-GGA-1678854] GUSB tetramer hydrolyses CS/HS precursor - Gallus gallus [Reaction:R-XTR-1678854] GUSB tetramer hydrolyses CS/HS precursor - Xenopus tropicalis [Reaction:R-DRE-1678854] GUSB tetramer hydrolyses CS/HS precursor - Danio rerio [Reaction:R-SSC-1678854] GUSB tetramer hydrolyses CS/HS precursor - Sus scrofa [Reaction:R-CFA-1678854] GUSB tetramer hydrolyses CS/HS precursor - Canis familiaris [Reaction:R-RNO-1678854] GUSB tetramer hydrolyses CS/HS precursor - Rattus norvegicus [Reaction:R-MMU-1678854] GUSB tetramer hydrolyses CS/HS precursor - Mus musculus
output	[SimpleEntity:R-ALL-1678868] GlcA [lysosomal lumen] [SimpleEntity:R-ALL-2090075] linker chain(2) [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-2090038] NAGLU hydrolyses heparan chain(2) - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-2090086] Negative regulation by 'L-Asp [lysosomal lumen]'
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1678854
summation	[Summation:1678861] The tetrameric lysosomal enzyme beta-glucuronidase (GUSB) hy...
updateTrackers	[UpdateTracker:9953590] Update Tracker - [Reaction:1678854] GUSB tetramer hydrolyses CS/HS precursor - v93:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9953590] Update Tracker - [Reaction:1678854] GUSB tetramer hydrolyses CS/HS precursor - v93:[modifyText, removeLiteratureReference]
(normalReaction)	[FailedReaction:R-HSA-9036070] Defective GUSB does not hydrolyse CS/HS precursor
(hasEvent)	[Pathway:R-HSA-2024101] CS/DS degradation
(precedingEvent)	[Reaction:R-HSA-2090079] GLB1 hydrolyses linker chain(2)