Reactome | FGFR2 point mutant dimers [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2077404] FGFR2 point mutant dimers:TKIs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2077424] Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors - Homo sapiens
created	[InstanceEdit:2077402] Rothfels, K, 2012-01-27
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2077401
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR2 point mutant dimers [plasma membrane]
hasMember	[CandidateSet:R-HSA-2029952] FGFR2 ligand-independent mutant dimers [plasma membrane] - Homo sapiens [Complex:R-HSA-2065929] FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane] - Homo sapiens [Complex:R-HSA-2065986] FGFR2c mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-2033349] FGFR2 mutant dimers with enhanced kinase activity [plasma membrane] - Homo sapiens
inDisease	true
maxDepth	5
name	FGFR2 point mutant dimers
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2077401
updateTrackers	[UpdateTracker:9900910] Update Tracker - [DefinedSet:2077401] FGFR2 point mutant dimers [plasma membrane] - v71:[updateContainedMemberOrCandidate] [UpdateTracker:9893354] Update Tracker - [DefinedSet:2077401] FGFR2 point mutant dimers [plasma membrane] - v56:[updateContainedMemberOrCandidate]

(updatedInstance)	[UpdateTracker:9900910] Update Tracker - [DefinedSet:2077401] FGFR2 point mutant dimers [plasma membrane] - v71:[updateContainedMemberOrCandidate] [UpdateTracker:9893354] Update Tracker - [DefinedSet:2077401] FGFR2 point mutant dimers [plasma membrane] - v56:[updateContainedMemberOrCandidate]
(hasComponent)	[Complex:R-HSA-2077404] FGFR2 point mutant dimers:TKIs [plasma membrane]
(input)	[Reaction:R-HSA-2077424] Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
(diseaseEntity)	[EntityFunctionalStatus:5654539] gain_of_function of FGFR2 point mutant dimers [plasma membrane]