Reactome | FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:2033450] protein tyrosine kinase activity of FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2033488] Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding - Homo sapiens
created	[InstanceEdit:2065928] Rothfels, K, 2012-01-24
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2065929
disease	[Disease:2032940] bone development disease [Disease:1500689] cancer
displayName	FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
hasComponent	[DefinedSet:R-HSA-2065927] FGFR2b mutant dimers with enhanced ligand-binding [plasma membrane] 2 × [DefinedSet:R-HSA-2065925] FGFR2b mutant-binding FGFs [extracellular region] [SimpleEntity:R-ALL-190915] HS [extracellular region]
inDisease	true
includedLocation	[Compartment:984] extracellular region
isChimeric	false
maxDepth	4
memberOf	[DefinedSet:R-HSA-2077401] FGFR2 point mutant dimers [plasma membrane] - Homo sapiens
name	FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs
producedByEvent	[Reaction:R-HSA-2033474] FGFR2b mutants bind an expanded range of ligands - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2065929

(hasMember)	[DefinedSet:R-HSA-2077401] FGFR2 point mutant dimers [plasma membrane]
(input)	[Reaction:R-HSA-2033488] Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
(diseaseEntity)	[EntityFunctionalStatus:5654454] gain_of_function of FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
(physicalEntity)	[CatalystActivity:2033450] protein tyrosine kinase activity of FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
(output)	[Reaction:R-HSA-2033474] FGFR2b mutants bind an expanded range of ligands

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