Reactome | FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]

Schema > CandidateSet > Entries

catalystActivities	[CatalystActivity:2033451] protein tyrosine kinase activity of FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2033490] Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity - Homo sapiens
created	[InstanceEdit:2033350] Rothfels, K, 2012-01-09
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2033349
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
hasCandidate	[Complex:R-HSA-2033339] FGFR2 K660E mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2033327] FGFR2 K660M mutant dimer [plasma membrane] - Homo sapiens
hasMember	[Complex:R-HSA-2033331] FGFR2 K660N mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2033329] FGFR2 N549K mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2033341] FGFR2 N549H mutant dimer [plasma membrane] - Homo sapiens
inDisease	true
maxDepth	3
memberOf	[DefinedSet:R-HSA-2077401] FGFR2 point mutant dimers [plasma membrane] - Homo sapiens
modified	[InstanceEdit:2065842] Rothfels, K, 2012-01-24
name	FGFR2 mutant dimers with enhanced kinase activity
producedByEvent	[Reaction:R-HSA-2033479] Dimerization of FGFR2 point mutants with enhanced kinase activity - Homo sapiens
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2033349

(hasMember)	[DefinedSet:R-HSA-2077401] FGFR2 point mutant dimers [plasma membrane]
(input)	[Reaction:R-HSA-2033490] Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
(diseaseEntity)	[EntityFunctionalStatus:5654452] gain_of_function of FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
(physicalEntity)	[CatalystActivity:2033451] protein tyrosine kinase activity of FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
(output)	[Reaction:R-HSA-2033479] Dimerization of FGFR2 point mutants with enhanced kinase activity

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