Reactome | FGFR2 ligand-independent mutant dimers [plasma membrane]

Schema > CandidateSet > Entries

FGFR2 ligand-independent mutant dimers [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:2029972] protein tyrosine kinase activity of FGFR2 ligand-independent mutant dimers [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2029984] Autocatalytic phosphorylation of FGFR2 ligand-independent mutants - Homo sapiens
created	[InstanceEdit:2029953] Rothfels, K, 2012-01-05
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2029952
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR2 ligand-independent mutant dimers [plasma membrane]
hasCandidate	[Complex:R-HSA-2029923] FGFR2b S373C mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2029924] FGFR2b Y376C mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2029919] FGFR2 W290C mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2029928] FGFR2c S372C mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2029936] FGFR2c Y375C mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2071927] FGFR2 L764fs*4STOP mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9667347] FGFR2b C382R mutant dimer [plasma membrane] - Homo sapiens
hasMember	[Complex:R-HSA-2033335] FGFR2 S267P mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2029930] FGFR2c W290G mutant dimer [plasma membrane] - Homo sapiens
inDisease	true
maxDepth	3
memberOf	[DefinedSet:R-HSA-2077401] FGFR2 point mutant dimers [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9667354] Rothfels, Karen, 2019-11-11
name	FGFR2 ligand-independent mutant dimers
producedByEvent	[Reaction:R-HSA-2029983] Dimerization of FGFR2 ligand-independent mutants - Homo sapiens
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2029952
updateTrackers	[UpdateTracker:9900912] Update Tracker - [CandidateSet:2029952] FGFR2 ligand-independent mutant dimers [plasma membrane] - v71:[addHasCandidate]

Referrals

(updatedInstance)	[UpdateTracker:9900912] Update Tracker - [CandidateSet:2029952] FGFR2 ligand-independent mutant dimers [plasma membrane] - v71:[addHasCandidate]
(hasMember)	[DefinedSet:R-HSA-2077401] FGFR2 point mutant dimers [plasma membrane]
(input)	[Reaction:R-HSA-2029984] Autocatalytic phosphorylation of FGFR2 ligand-independent mutants
(diseaseEntity)	[EntityFunctionalStatus:5654449] gain_of_function of FGFR2 ligand-independent mutant dimers [plasma membrane]
(physicalEntity)	[CatalystActivity:2029972] protein tyrosine kinase activity of FGFR2 ligand-independent mutant dimers [plasma membrane]
(output)	[Reaction:R-HSA-2029983] Dimerization of FGFR2 ligand-independent mutants