Direct recruitment of PI3K to p-KIT

Stable Identifier
R-HSA-205262
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The regulatory subunit (p85) of PI3K interacts directly with phosphorylated Y721 of KIT via one of its SH2 domains. This binding leads to the activation of the catalytic domain (p110) of PI3K. SCF-induced PI3K recruitment mediates AKT activation through phospholipids at the membrane and to subsequent phosphorylation of the pro-apoptotic factor Bad as well as Fox3a.
PI3K activation mediates SCF-induced cell proliferation, survival, differentiation, adhesion, secretion and actin cytoskeletal organization.

Literature References
PubMed ID Title Journal Year
16483568 Stem cell factor and its receptor c-Kit as targets for inflammatory diseases

Reber, L, Da Silva, CA, Frossard, N

Eur J Pharmacol 2006
15526160 Signal transduction via the stem cell factor receptor/c-Kit

Rönnstrand, L

Cell Mol Life Sci 2004
11520784 Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant

Chian, R, Young, S, Danilkovitch-Miagkova, A, Rönnstrand, L, Leonard, E, Ferrao, P, Ashman, L, Linnekin, D

Blood 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created