The regulatory subunit (p85) of PI3K interacts directly with phosphorylated Y721 of KIT via one of its SH2 domains. This binding leads to the activation of the catalytic domain (p110) of PI3K. SCF-induced PI3K recruitment mediates AKT activation through phospholipids at the membrane and to subsequent phosphorylation of the pro-apoptotic factor Bad as well as Fox3a.PI3K activation mediates SCF-induced cell proliferation, survival, differentiation, adhesion, secretion and actin cytoskeletal organization.
Rönnstrand, L
Frossard, N, Da Silva, CA, Reber, L
Young, S, Leonard, E, Chian, R, Ferrao, P, Danilkovitch-Miagkova, A, Linnekin, D, Ashman, L, Rönnstrand, L
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