Reactome | alpha-linolenic acid (ALA) metabolism

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alpha-linolenic acid (ALA) metabolism Show undefined attributes

authored	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:17951] peroxisomal matrix [Compartment:17947] peroxisomal membrane
created	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
dbId	2046106
displayName	alpha-linolenic acid (ALA) metabolism
edited	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
eventOf	[Pathway:R-HSA-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2132694] alpha-linolenic acid metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Homo sapiens [Reaction:R-HSA-2046084] Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA - Homo sapiens [Reaction:R-HSA-2046088] Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA - Homo sapiens [Reaction:R-HSA-2046089] Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA - Homo sapiens [Reaction:R-HSA-2046100] Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA - Homo sapiens [Reaction:R-HSA-2046090] Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA - Homo sapiens [Reaction:R-HSA-2046099] Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA - Homo sapiens [Reaction:R-HSA-2046087] Translocation of tetracosahexaenoyl-CoA to peroxisomes - Homo sapiens [Reaction:R-HSA-2066787] Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA - Homo sapiens [Reaction:R-HSA-2066778] Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA - Homo sapiens [Reaction:R-HSA-2066780] Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA - Homo sapiens [Reaction:R-HSA-2066781] Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) - Homo sapiens [Reaction:R-HSA-2066788] Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase - Homo sapiens [Reaction:R-HSA-2066779] Conversion of DHA-CoA to docosahexaenoic acid (DHA) - Homo sapiens [BlackBoxEvent:R-HSA-2066785] Retranslocation of DHA back to ER - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2046004] Desaturation and chain elongation of n - 3 and n - 6 polyunsaturated fatty acids in the human CaCo-2 cell line [LiteratureReference:2046003] Metabolism of alpha-linolenic acid in humans
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	alpha-linolenic acid (ALA) metabolism
orthologousEvent	[Pathway:R-PFA-2046106] alpha-linolenic acid (ALA) metabolism - Plasmodium falciparum [Pathway:R-SCE-2046106] alpha-linolenic acid (ALA) metabolism - Saccharomyces cerevisiae [Pathway:R-DDI-2046106] alpha-linolenic acid (ALA) metabolism - Dictyostelium discoideum [Pathway:R-CEL-2046106] alpha-linolenic acid (ALA) metabolism - Caenorhabditis elegans [Pathway:R-DME-2046106] alpha-linolenic acid (ALA) metabolism - Drosophila melanogaster [Pathway:R-GGA-2046106] alpha-linolenic acid (ALA) metabolism - Gallus gallus [Pathway:R-XTR-2046106] alpha-linolenic acid (ALA) metabolism - Xenopus tropicalis [Pathway:R-DRE-2046106] alpha-linolenic acid (ALA) metabolism - Danio rerio [Pathway:R-SSC-2046106] alpha-linolenic acid (ALA) metabolism - Sus scrofa [Pathway:R-BTA-2046106] alpha-linolenic acid (ALA) metabolism - Bos taurus [Pathway:R-CFA-2046106] alpha-linolenic acid (ALA) metabolism - Canis familiaris [Pathway:R-RNO-2046106] alpha-linolenic acid (ALA) metabolism - Rattus norvegicus [Pathway:R-MMU-2046106] alpha-linolenic acid (ALA) metabolism - Mus musculus
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2046106
summation	[Summation:2066730] Alpha-linolenic acid (ALA, 18:3(n-3)) is an omega-3 fatty ac...

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[Pathway:R-HSA-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

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