Reactome | alpha-linolenic acid (ALA) metabolism

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alpha-linolenic acid (ALA) metabolism Show undefined attributes

compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:17951] peroxisomal matrix [Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100865
displayName	alpha-linolenic acid (ALA) metabolism
eventOf	[Pathway:R-MMU-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2132694] alpha-linolenic acid metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Mus musculus [Reaction:R-MMU-2046084] Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA - Mus musculus [Reaction:R-MMU-2046088] Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA - Mus musculus [Reaction:R-MMU-2046089] Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA - Mus musculus [Reaction:R-MMU-2046100] Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA - Mus musculus [Reaction:R-MMU-2046090] Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA - Mus musculus [Reaction:R-MMU-2046087] Translocation of tetracosahexaenoyl-CoA to peroxisomes - Mus musculus [Reaction:R-MMU-2066787] Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA - Mus musculus [Reaction:R-MMU-2066778] Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA - Mus musculus [Reaction:R-MMU-2066780] Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA - Mus musculus [Reaction:R-MMU-2066781] Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) - Mus musculus [Reaction:R-MMU-2066788] Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase - Mus musculus [Reaction:R-MMU-2066779] Conversion of DHA-CoA to docosahexaenoic acid (DHA) - Mus musculus
inferredFrom	[Pathway:R-HSA-2046106] alpha-linolenic acid (ALA) metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	alpha-linolenic acid (ALA) metabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-2046106
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
(inferredTo)	[Pathway:R-HSA-2046106] alpha-linolenic acid (ALA) metabolism

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