Reactome | Activation of alpha-linolenic acid to alpha-linolenoyl-CoA

Schema > Reaction > Entries

Activation of alpha-linolenic acid to alpha-linolenoyl-CoA Show undefined attributes

authored	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
catalystActivity	[CatalystActivity:2046080] long-chain fatty acid-CoA ligase activity of ACSL1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:2046086] Garapati, P V, 2012-01-11
crossReference	[DatabaseIdentifier:12668407] RHEA:44936
dbId	2046085
displayName	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA
edited	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
eventOf	[Pathway:R-HSA-2046106] alpha-linolenic acid (ALA) metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-2046084] Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-2046056] ALA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-211579] ATP [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-162743] CoA-SH [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[Book:2066717] Biosketch, M 978-0-12-417762-8 Docosahexaenoic acid Nutrient Metabolism [LiteratureReference:2066750] Discovery of an arachidonoyl coenzyme A synthetase in human platelets
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Activation of alpha-linolenic acid to alpha-linolenoyl-CoA
orthologousEvent	[Reaction:R-PFA-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Plasmodium falciparum [Reaction:R-SCE-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Saccharomyces cerevisiae [Reaction:R-DDI-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Caenorhabditis elegans [Reaction:R-GGA-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Gallus gallus [Reaction:R-XTR-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Xenopus tropicalis [Reaction:R-DRE-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Danio rerio [Reaction:R-SSC-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Sus scrofa [Reaction:R-BTA-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Bos taurus [Reaction:R-CFA-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Canis familiaris [Reaction:R-RNO-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Rattus norvegicus [Reaction:R-MMU-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-2046064] adenosine 5'-monophosphate [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-2046062] ALA-CoA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2046049] PPi [endoplasmic reticulum membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2046085
summation	[Summation:2045943] In the first step the precursor apha-linolenic (9,12,15-18:3...

Referrals

(hasEvent)	[Pathway:R-HSA-2046106] alpha-linolenic acid (ALA) metabolism
(precedingEvent)	[Reaction:R-HSA-2046084] Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA