Reactome | alpha-linolenic acid (ALA) metabolism

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alpha-linolenic acid (ALA) metabolism Show undefined attributes

compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:17951] peroxisomal matrix [Compartment:17947] peroxisomal membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330903
displayName	alpha-linolenic acid (ALA) metabolism
eventOf	[Pathway:R-CFA-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2132694] alpha-linolenic acid metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA - Canis familiaris [Reaction:R-CFA-2046084] Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA - Canis familiaris [Reaction:R-CFA-2046088] Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA - Canis familiaris [Reaction:R-CFA-2046089] Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA - Canis familiaris [Reaction:R-CFA-2046100] Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA - Canis familiaris [Reaction:R-CFA-2046090] Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA - Canis familiaris [Reaction:R-CFA-2046087] Translocation of tetracosahexaenoyl-CoA to peroxisomes - Canis familiaris [Reaction:R-CFA-2066787] Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA - Canis familiaris [Reaction:R-CFA-2066778] Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA - Canis familiaris [Reaction:R-CFA-2066780] Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA - Canis familiaris [Reaction:R-CFA-2066781] Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) - Canis familiaris [Reaction:R-CFA-2066788] Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase - Canis familiaris [Reaction:R-CFA-2066779] Conversion of DHA-CoA to docosahexaenoic acid (DHA) - Canis familiaris
inferredFrom	[Pathway:R-HSA-2046106] alpha-linolenic acid (ALA) metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	alpha-linolenic acid (ALA) metabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-2046106
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
(inferredTo)	[Pathway:R-HSA-2046106] alpha-linolenic acid (ALA) metabolism

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