Reactome | Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10466823
displayName	Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-SSC-167542] CD4 [plasma membrane] [Complex:R-SSC-203463] MHC Class II bearing antigen peptide [plasma membrane] [EntityWithAccessionedSequence:R-SSC-202308] phospho-p-Y394-LCK [cytosol] [Complex:R-SSC-203493] T-cell receptor complex with phosphorylated ITAMs [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - Homo sapiens
maxDepth	6
name	Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4
producedByEvent	[Reaction:R-SSC-202165] Phosphorylation of ITAM motifs in CD3 complexes - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-203494
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-SSC-389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
(output)	[Reaction:R-SSC-202165] Phosphorylation of ITAM motifs in CD3 complexes
(hasComponent)	[Complex:R-SSC-202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] [Complex:R-SSC-202345] phospho tyrosine ZAP-70 [plasma membrane] [Complex:R-SSC-202181] Activated ZAP-70 [plasma membrane]
(inferredTo)	[Complex:R-HSA-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]

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