Reactome | Phosphorylation and activation of PLCG

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Phosphorylation and activation of PLCG Show undefined attributes

authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
catalystActivity	[CatalystActivity:2029255] protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643489] protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:2029269] Garapati, P V, 2012-01-04
dbId	2029268
displayName	Phosphorylation and activation of PLCG
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
eventOf	[Pathway:R-HSA-2029485] Role of phospholipids in phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-2029272] Release of PLCG from FCGR - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2029137] clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028806] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk [LiteratureReference:2028992] Tyrosine phosphorylation of phospholipase C-gamma 2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils [LiteratureReference:1168981] Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation and activation of PLCG
orthologousEvent	[Reaction:R-GGA-2029268] Phosphorylation and activation of PLCG - Gallus gallus [Reaction:R-SSC-2029268] Phosphorylation and activation of PLCG - Sus scrofa [Reaction:R-BTA-2029268] Phosphorylation and activation of PLCG - Bos taurus [Reaction:R-CFA-2029268] Phosphorylation and activation of PLCG - Canis familiaris [Reaction:R-RNO-2029268] Phosphorylation and activation of PLCG - Rattus norvegicus [Reaction:R-MMU-2029268] Phosphorylation and activation of PLCG - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2029156] clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane]
precedingEvent	[Reaction:R-HSA-2029270] Recruitment of PLCgamma to membrane - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2029268
summation	[Summation:2028840] PLCG is tyrosine phosphorylated by either SYK or Src kinases...

Referrals

(hasEvent)	[Pathway:R-HSA-2029485] Role of phospholipids in phagocytosis
(precedingEvent)	[Reaction:R-HSA-2029272] Release of PLCG from FCGR