Reactome | Autophosphorylation of PAK1,2,3

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Autophosphorylation of PAK1,2,3 Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity	[CatalystActivity:5627776] protein serine/threonine kinase activity of CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5627774] Orlic-Milacic, Marija, 2014-10-20
dbId	5627775
displayName	Autophosphorylation of PAK1,2,3
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02 [InstanceEdit:8981977] Orlic-Milacic, Marija, 2017-03-15
eventOf	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling - Homo sapiens [Pathway:R-HSA-5627123] RHO GTPases activate PAKs - Homo sapiens
followingEvent	[Reaction:R-HSA-5687086] PAK1,2,3 phosphorylates MAPK6,4 - Homo sapiens [Reaction:R-HSA-442832] PAK phosphorylates cortactin - Homo sapiens [Reaction:R-HSA-5668932] PAK2 phosphorylates myosin regulatory light chain (MRLC) - Homo sapiens [Reaction:R-HSA-5669240] FLNA binds PAK1 - Homo sapiens [Reaction:R-HSA-5668984] PAK1 or PAK2 phosphorylates MYLK - Homo sapiens [Reaction:R-HSA-2029460] PAK1 phosphorylates LIMK1 - Homo sapiens [Reaction:R-HSA-5668947] PAK1 phosphorylates myosin phosphatase - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-8981940] CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 [LiteratureReference:399908] The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity [LiteratureReference:5627780] Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch [LiteratureReference:5627787] Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification [LiteratureReference:211590] Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	Autophosphorylation of PAK1,2,3
orthologousEvent	[Reaction:R-SCE-5627775] Autophosphorylation of PAK1,2,3 - Saccharomyces cerevisiae [Reaction:R-SPO-5627775] Autophosphorylation of PAK1,2,3 - Schizosaccharomyces pombe [Reaction:R-DDI-5627775] Autophosphorylation of PAK1,2,3 - Dictyostelium discoideum [Reaction:R-CEL-5627775] Autophosphorylation of PAK1,2,3 - Caenorhabditis elegans [Reaction:R-DME-5627775] Autophosphorylation of PAK1,2,3 - Drosophila melanogaster [Reaction:R-GGA-5627775] Autophosphorylation of PAK1,2,3 - Gallus gallus [Reaction:R-XTR-5627775] Autophosphorylation of PAK1,2,3 - Xenopus tropicalis [Reaction:R-DRE-5627775] Autophosphorylation of PAK1,2,3 - Danio rerio [Reaction:R-SSC-5627775] Autophosphorylation of PAK1,2,3 - Sus scrofa [Reaction:R-BTA-5627775] Autophosphorylation of PAK1,2,3 - Bos taurus [Reaction:R-CFA-5627775] Autophosphorylation of PAK1,2,3 - Canis familiaris [Reaction:R-RNO-5627775] Autophosphorylation of PAK1,2,3 - Rattus norvegicus [Reaction:R-MMU-5627775] Autophosphorylation of PAK1,2,3 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 3 × [DefinedSet:R-HSA-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [DefinedSet:R-HSA-399836] p-S,T-PAK1,2,3 [cytosol]
precedingEvent	[Reaction:R-HSA-2029456] RAC1 and CDC42 activate PAK1 - Homo sapiens [Reaction:R-HSA-8981931] RAC1 and CDC42 activate PAK2 - Homo sapiens [Reaction:R-HSA-8981926] RAC1 and CDC42 activate PAK3 - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5627775
summation	[Summation:5627788] Binding of PAK1, PAK2 or PAK3 to GTP-bound RAC1 or CDC42 dis...
systematicName	Complexed PAK1,2,3 autophosphorylate

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