Caspase mediated cleavage of desmoglein 1 leads to decreased expression at the cell surface and re-localization of its C terminus diffusely throughout the cytoplasm. Cleavage is thought to contribute to the dismantling of desmosomes during keratinocyte apoptosis (Dusek et al., 2006).
Green, KJ, Getsios, S, Dusek, RL, Cryns, VL, Chen, F, Amargo, EV, Park, JK
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
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