Reactome | Cleavage of p-STK3 (p-MST2) by caspase 3

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Cleavage of p-STK3 (p-MST2) by caspase 3 Show undefined attributes

authored	[InstanceEdit:2085531] D'Eustachio, P, 2012-02-03
catalystActivity	[CatalystActivity:114327] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2028678] D'Eustachio, P, 2011-12-30
dbId	2028697
displayName	Cleavage of p-STK3 (p-MST2) by caspase 3
edited	[InstanceEdit:2028654] D'Eustachio, P, 2011-12-30
eventOf	[Pathway:R-HSA-2028269] Signaling by Hippo - Homo sapiens
followingEvent	[Reaction:R-HSA-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Homo sapiens [Reaction:R-HSA-2028673] Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N - Homo sapiens
input	[Complex:R-HSA-2028261] p-STK3:p-SAV1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028689] MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Cleavage of p-STK3 (p-MST2) by caspase 3
orthologousEvent	[Reaction:R-CFA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Canis familiaris [Reaction:R-DME-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Drosophila melanogaster [Reaction:R-GGA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Gallus gallus [Reaction:R-XTR-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Xenopus tropicalis [Reaction:R-DRE-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Danio rerio [Reaction:R-SSC-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Sus scrofa [Reaction:R-BTA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Bos taurus [Reaction:R-RNO-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Rattus norvegicus [Reaction:R-MMU-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Mus musculus
output	[Complex:R-HSA-2028690] p-STK3/N:p-SAV1 [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-2028684] STK3(323-491) [cytosol]
precedingEvent	[Reaction:R-HSA-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2085532] Sudol, M, 2012-02-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2028697
summation	[Summation:2028695] Cytosolic caspase 3 cleaves p-STK3 (p-MST2) to yield an acti...

Referrals

(hasEvent)	[Pathway:R-HSA-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-HSA-2028673] Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N [Reaction:R-HSA-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N