Reactome | Cleavage of p-STK3 (p-MST2) by caspase 3

Cleavage of p-STK3 (p-MST2) by caspase 3

Stable Identifier

R-HSA-2028697

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cleavage of p-STK3 (p-MST2) by caspase 3

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Cytosolic caspase 3 cleaves p-STK3 (p-MST2) to yield an active animo-terminal fragment (p-STK3/N) and a carboxy-terminal fragment (p-STK3/C) (Lee et al. 2001). The association of p-STK3 (p-MST2) with other proteins at the time of its cleavage by caspase has not been studied experimentally. Here, it is inferred to be dimerized and in a complex with SAV1 because that is the form of the molecule that becomes phosphorylated and phosphorylation appears normally to precede caspase cleavage. The effect of the cleavage is to increase the kinase activity of p-STK3 (p-MST2).

Literature References

PubMed ID	Title	Journal	Year
11278283	MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation Lee, KK, Ohyama, T, Yajima, N, Tsubuki, S, Yonehara, S	J Biol Chem	2001