Reactome | Phosphorylation of MOB1A and B by p-STK3(MST2)/N

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Phosphorylation of MOB1A and B by p-STK3(MST2)/N Show undefined attributes

authored	[InstanceEdit:2085531] D'Eustachio, P, 2012-02-03
catalystActivity	[CatalystActivity:2028693] protein serine/threonine kinase activity of p-STK3/N:p-SAV1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643212] protein serine/threonine kinase activity of p-STK3/N:p-SAV1 [cytosol] MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2028678] D'Eustachio, P, 2011-12-30
dbId	2028675
displayName	Phosphorylation of MOB1A and B by p-STK3(MST2)/N
edited	[InstanceEdit:2028654] D'Eustachio, P, 2011-12-30
eventOf	[Pathway:R-HSA-2028269] Signaling by Hippo - Homo sapiens
followingEvent	[Reaction:R-HSA-2028626] Phosphorylated MOB1A proteins associate with LATS proteins - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-2028544] MOB1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028689] MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of MOB1A and B by p-STK3(MST2)/N
orthologousEvent	[Reaction:R-CFA-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Canis familiaris [Reaction:R-CEL-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Caenorhabditis elegans [Reaction:R-DME-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Drosophila melanogaster [Reaction:R-GGA-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Gallus gallus [Reaction:R-XTR-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Xenopus tropicalis [Reaction:R-DRE-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Danio rerio [Reaction:R-SSC-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Sus scrofa [Reaction:R-BTA-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Bos taurus [Reaction:R-RNO-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Rattus norvegicus [Reaction:R-MMU-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-2028620] p-MOB1 [cytosol]
precedingEvent	[Reaction:R-HSA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2085532] Sudol, M, 2012-02-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2028675
summation	[Summation:2028676] Cytosolic MOB1A and MOB1B are phosphorylated by phospho-STK3...

Referrals

(hasEvent)	[Pathway:R-HSA-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-HSA-2028626] Phosphorylated MOB1A proteins associate with LATS proteins