Reactome | Cleavage of p-STK3 (p-MST2) by caspase 3

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Cleavage of p-STK3 (p-MST2) by caspase 3 Show undefined attributes

catalystActivity	[CatalystActivity:10665556] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10688081
displayName	Cleavage of p-STK3 (p-MST2) by caspase 3
eventOf	[Pathway:R-XTR-2028269] Signaling by Hippo - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Xenopus tropicalis [Reaction:R-XTR-2028673] Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Homo sapiens
input	[Complex:R-XTR-2028261] p-STK3:p-SAV1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of p-STK3 (p-MST2) by caspase 3
output	[Complex:R-XTR-2028690] p-STK3/N:p-SAV1 [cytosol] 2 × [EntityWithAccessionedSequence:R-XTR-2028684] STK3(323-491) [cytosol]
precedingEvent	[Reaction:R-XTR-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2028697
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-XTR-2028673] Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N [Reaction:R-XTR-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N
(inferredTo)	[Reaction:R-HSA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3

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