Reactome | Phosphorylation of STK3 (MST2) and SAV1 by STK3

Schema > Reaction > Entries

Phosphorylation of STK3 (MST2) and SAV1 by STK3 Show undefined attributes

authored	[InstanceEdit:2085531] D'Eustachio, P, 2012-02-03
catalystActivity	[CatalystActivity:2028254] protein serine/threonine kinase activity of STK3:SAV1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9644054] protein serine/threonine kinase activity of STK3:SAV1 [cytosol] Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2028547] D'Eustachio, P, 2011-12-28
dbId	2028591
displayName	Phosphorylation of STK3 (MST2) and SAV1 by STK3
edited	[InstanceEdit:2028654] D'Eustachio, P, 2011-12-30
eventOf	[Pathway:R-HSA-2028269] Signaling by Hippo - Homo sapiens
followingEvent	[Reaction:R-HSA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Homo sapiens [Reaction:R-HSA-2028635] Phosphorylation of MOB1A and B by p-STK3 (p-MST2) - Homo sapiens [Reaction:R-HSA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2028275] STK3:SAV1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028239] Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation [LiteratureReference:2028272] Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras [LiteratureReference:2028282] The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of STK3 (MST2) and SAV1 by STK3
orthologousEvent	[Reaction:R-CFA-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Canis familiaris [Reaction:R-CEL-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Caenorhabditis elegans [Reaction:R-DME-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Drosophila melanogaster [Reaction:R-GGA-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Gallus gallus [Reaction:R-XTR-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Xenopus tropicalis [Reaction:R-DRE-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Danio rerio [Reaction:R-SSC-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Sus scrofa [Reaction:R-BTA-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Bos taurus [Reaction:R-RNO-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Rattus norvegicus [Reaction:R-MMU-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2028261] p-STK3:p-SAV1 [cytosol]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2085532] Sudol, M, 2012-02-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2028591
summation	[Summation:2028561] The serine/threonine kinase STK3 (MST2) catalyzes its own au...

Referrals

(hasEvent)	[Pathway:R-HSA-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-HSA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) [Reaction:R-HSA-2028635] Phosphorylation of MOB1A and B by p-STK3 (p-MST2) [Reaction:R-HSA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3

Cite Us!