Reactome | Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)

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Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) Show undefined attributes

authored	[InstanceEdit:2085531] D'Eustachio, P, 2012-02-03
catalystActivity	[CatalystActivity:2028573] protein serine/threonine kinase activity of p-STK3:p-SAV1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643879] protein serine/threonine kinase activity of p-STK3:p-SAV1 [cytosol] The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2028547] D'Eustachio, P, 2011-12-28
dbId	2028589
displayName	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
edited	[InstanceEdit:2028654] D'Eustachio, P, 2011-12-30
eventOf	[Pathway:R-HSA-2028269] Signaling by Hippo - Homo sapiens
followingEvent	[Reaction:R-HSA-2028598] Phosphorylation of YAP by LATS1 - Homo sapiens [Reaction:R-HSA-2028583] Phosphorylation of YAP by LATS2 - Homo sapiens [Reaction:R-HSA-2028661] Phosphorylation of WWTR1 (TAZ) by LATS2 - Homo sapiens [Reaction:R-HSA-2060328] Phosphorylation of WWTR1 (TAZ) by LATS1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2028543] LATS:p-MOB [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028282] The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
orthologousEvent	[Reaction:R-CFA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Canis familiaris [Reaction:R-CEL-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Caenorhabditis elegans [Reaction:R-DME-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Drosophila melanogaster [Reaction:R-GGA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Gallus gallus [Reaction:R-XTR-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Xenopus tropicalis [Reaction:R-DRE-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Danio rerio [Reaction:R-SSC-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Sus scrofa [Reaction:R-BTA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Bos taurus [Reaction:R-RNO-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Rattus norvegicus [Reaction:R-MMU-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2028550] p-LATS:p-MOB [cytosol]
precedingEvent	[Reaction:R-HSA-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Homo sapiens [Reaction:R-HSA-2028626] Phosphorylated MOB1A proteins associate with LATS proteins - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2085532] Sudol, M, 2012-02-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2028589
summation	[Summation:2028599] Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK3...
updateTrackers	[UpdateTracker:9846725] Update Tracker - [Reaction:2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - v84:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9846725] Update Tracker - [Reaction:2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - v84:[modifyText]
(hasEvent)	[Pathway:R-HSA-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-HSA-2028598] Phosphorylation of YAP by LATS1 [Reaction:R-HSA-2028583] Phosphorylation of YAP by LATS2 [Reaction:R-HSA-2028661] Phosphorylation of WWTR1 (TAZ) by LATS2 [Reaction:R-HSA-2060328] Phosphorylation of WWTR1 (TAZ) by LATS1