Reactome | Phosphorylation of YAP by LATS2

Schema > Reaction > Entries

Phosphorylation of YAP by LATS2 Show undefined attributes

authored	[InstanceEdit:2085531] D'Eustachio, P, 2012-02-03
catalystActivity	[CatalystActivity:2028546] protein serine/threonine kinase activity of p-LATS2:p-MOB1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2028547] D'Eustachio, P, 2011-12-28
dbId	2028583
displayName	Phosphorylation of YAP by LATS2
edited	[InstanceEdit:2028654] D'Eustachio, P, 2011-12-30
eventOf	[Pathway:R-HSA-2028269] Signaling by Hippo - Homo sapiens
followingEvent	[Reaction:R-HSA-2028644] YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-1253345] YAP1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028574] Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control [LiteratureReference:2028237] Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor [LiteratureReference:2028252] Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of YAP by LATS2
orthologousEvent	[Reaction:R-CFA-2028583] Phosphorylation of YAP by LATS2 - Canis familiaris [Reaction:R-CEL-2028583] Phosphorylation of YAP by LATS2 - Caenorhabditis elegans [Reaction:R-DME-2028583] Phosphorylation of YAP by LATS2 - Drosophila melanogaster [Reaction:R-GGA-2028583] Phosphorylation of YAP by LATS2 - Gallus gallus [Reaction:R-XTR-2028583] Phosphorylation of YAP by LATS2 - Xenopus tropicalis [Reaction:R-DRE-2028583] Phosphorylation of YAP by LATS2 - Danio rerio [Reaction:R-SSC-2028583] Phosphorylation of YAP by LATS2 - Sus scrofa [Reaction:R-BTA-2028583] Phosphorylation of YAP by LATS2 - Bos taurus [Reaction:R-RNO-2028583] Phosphorylation of YAP by LATS2 - Rattus norvegicus [Reaction:R-MMU-2028583] Phosphorylation of YAP by LATS2 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-2028553] p-S127-YAP1 [cytosol]
precedingEvent	[Reaction:R-HSA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Homo sapiens [Reaction:R-HSA-2028555] Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) - Homo sapiens [Reaction:R-HSA-2028673] Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N - Homo sapiens [Reaction:R-HSA-2028679] Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-2028608] Positive regulation by 'AMOT proteins [cytosol]'
regulationReference	[RegulationReference:9641435] Positive regulation by 'AMOT proteins [cytosol]' Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2085532] Sudol, M, 2012-02-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2028583
summation	[Summation:2028600] Cytosolic phospho-LATS2, complexed with MOB1, catalyzes the ...

Referrals

(hasEvent)	[Pathway:R-HSA-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-HSA-2028644] YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1

Cite Us!