Reactome | Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)

Schema > Reaction > Entries

Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) Show undefined attributes

catalystActivity	[CatalystActivity:10385018] protein serine/threonine kinase activity of p-STK3:p-SAV1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10385020
displayName	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
eventOf	[Pathway:R-BTA-2028269] Signaling by Hippo - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-2028598] Phosphorylation of YAP by LATS1 - Bos taurus [Reaction:R-BTA-2028583] Phosphorylation of YAP by LATS2 - Bos taurus [Reaction:R-BTA-2028661] Phosphorylation of WWTR1 (TAZ) by LATS2 - Bos taurus [Reaction:R-BTA-2060328] Phosphorylation of WWTR1 (TAZ) by LATS1 - Bos taurus
inferredFrom	[Reaction:R-HSA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-2028543] LATS:p-MOB [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-2028550] p-LATS:p-MOB [cytosol]
precedingEvent	[Reaction:R-BTA-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Bos taurus [Reaction:R-BTA-2028626] Phosphorylated MOB1A proteins associate with LATS proteins - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2028589
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-BTA-2028598] Phosphorylation of YAP by LATS1 [Reaction:R-BTA-2028583] Phosphorylation of YAP by LATS2 [Reaction:R-BTA-2028661] Phosphorylation of WWTR1 (TAZ) by LATS2 [Reaction:R-BTA-2060328] Phosphorylation of WWTR1 (TAZ) by LATS1
(inferredTo)	[Reaction:R-HSA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)