Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK3...

created [InstanceEdit:2028547] D'Eustachio, P, 2011-12-28
dbId 2028599
displayName Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK3...
modified [InstanceEdit:9822895] D'Eustachio, Peter, 2022-12-30
schemaClass Summation
text Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK3 (p-MST2). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Likewise, phosphorylated (active) STK3 (p-MST2) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Serine-909 and threonine-1079 have been identified as LATS1 residues phosphorylated by STK4 kinase (MST1); STK3 (MST2) is inferred to act similarly. The target residues of LATS2 have not been identified experimentally but are inferred to be serine-872 and threonine-1041 based on sequence similarity (Chan et al. 2005).
Cite Us!