Reactome | Generation of second messenger molecules

Schema > Pathway > Entries

Generation of second messenger molecules Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:202434] Garapati, P V, 2007-10-29 15:25:21
crossReference	[DatabaseIdentifier:12819469] BioModels Database:BIOMD0000000724
dbId	202433
displayName	Generation of second messenger molecules
eventOf	[Pathway:R-HSA-202403] TCR signaling - Homo sapiens
figure	[Figure:9689488] /figures/static/R-HSA-202433.svg
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-202245] Phosphorylation of TBSMs in LAT - Homo sapiens [Reaction:R-HSA-202325] Recruitment of Gads to LAT - Homo sapiens [Reaction:R-HSA-202241] Recruitment of SLP-76 to Gads - Homo sapiens [Reaction:R-HSA-202216] Phosphorylation of SLP-76 - Homo sapiens [Reaction:R-HSA-202375] Recruitment of ITK to SLP-76 - Homo sapiens [Reaction:R-HSA-202331] Recruitment of PLC-gamma1 to SLP-76 - Homo sapiens [Reaction:R-HSA-202212] Recruitment of PLC-gamma1 to LAT - Homo sapiens [Reaction:R-HSA-202248] Phosphorylation of PLC-gamma1 - Homo sapiens [Reaction:R-HSA-213406] Disassociation of PLC-gamma1 from LAT - Homo sapiens [Reaction:R-HSA-213407] Disassociation of PLC-gamma1 from SLP-76 - Homo sapiens [Reaction:R-HSA-202354] Translocation of PLC-gamma1 to PIP2 - Homo sapiens [Reaction:R-HSA-202407] PLC-gamma1 hydrolyses PIP2 - Homo sapiens [Reaction:R-HSA-430135] p-SLP-76 binds ADAP - Homo sapiens [Reaction:R-HSA-430201] p-SLP-76:ADAP binds Ena/VASP - Homo sapiens [Reaction:R-HSA-430190] p-SLP-76 binds NCK - Homo sapiens [Reaction:R-HSA-430183] NCK binds PAK - Homo sapiens [Reaction:R-HSA-430180] NCK recruits WASP - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:202217] T cell receptor signaling: beyond complex complexes
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Generation of second messenger molecules
orthologousEvent	[Pathway:R-MMU-202433] Generation of second messenger molecules - Mus musculus [Pathway:R-RNO-202433] Generation of second messenger molecules - Rattus norvegicus [Pathway:R-BTA-202433] Generation of second messenger molecules - Bos taurus [Pathway:R-SSC-202433] Generation of second messenger molecules - Sus scrofa [Pathway:R-DRE-202433] Generation of second messenger molecules - Danio rerio [Pathway:R-XTR-202433] Generation of second messenger molecules - Xenopus tropicalis [Pathway:R-GGA-202433] Generation of second messenger molecules - Gallus gallus [Pathway:R-DME-202433] Generation of second messenger molecules - Drosophila melanogaster [Pathway:R-CEL-202433] Generation of second messenger molecules - Caenorhabditis elegans [Pathway:R-DDI-202433] Generation of second messenger molecules - Dictyostelium discoideum [Pathway:R-SPO-202433] Generation of second messenger molecules - Schizosaccharomyces pombe [Pathway:R-SCE-202433] Generation of second messenger molecules - Saccharomyces cerevisiae [Pathway:R-PFA-202433] Generation of second messenger molecules - Plasmodium falciparum [Pathway:R-CFA-202433] Generation of second messenger molecules - Canis familiaris
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-202433
summation	[Summation:202652] In addition to serving as a scaffold via auto-phosphorylatio...
updateTrackers	[UpdateTracker:9790418] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v33:[updateContainedRLE] [UpdateTracker:9791321] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v31:[addHasEvent] [UpdateTracker:9789136] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v38:[addLiteratureReference, modifyText] [UpdateTracker:9791110] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v32:[updateContainedRLE] [UpdateTracker:9783320] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v57:[updateContainedRLE] [UpdateTracker:9775893] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v78:[updateContainedRLE] [UpdateTracker:9781405] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v61:[updateContainedRLE] [UpdateTracker:9788461] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v42:[updateContainedRLE] [UpdateTracker:9776967] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v73:[modifyText]

Referrals

(hasEvent)

[Pathway:R-HSA-202403] TCR signaling

(updatedInstance)

[UpdateTracker:9790418] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v33:[updateContainedRLE]
[UpdateTracker:9791321] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v31:[addHasEvent]
[UpdateTracker:9789136] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9791110] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v32:[updateContainedRLE]
[UpdateTracker:9783320] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v57:[updateContainedRLE]
[UpdateTracker:9775893] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v78:[updateContainedRLE]
[UpdateTracker:9781405] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v61:[updateContainedRLE]
[UpdateTracker:9788461] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v42:[updateContainedRLE]
[UpdateTracker:9776967] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v73:[modifyText]

Cite Us!