Reactome | Phosphorylation of TBSMs in LAT

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Phosphorylation of TBSMs in LAT Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202262] protein tyrosine kinase activity of Activated ZAP-70 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
dbId	202245
displayName	Phosphorylation of TBSMs in LAT
eventOf	[Pathway:R-HSA-202433] Generation of second messenger molecules - Homo sapiens
followingEvent	[Reaction:R-HSA-202212] Recruitment of PLC-gamma1 to LAT - Homo sapiens [Reaction:R-HSA-202325] Recruitment of Gads to LAT - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-202322] LAT [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202315] Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. [LiteratureReference:202179] Hematopoietic adaptors in T-cell signaling: potential applications to transplantation [LiteratureReference:202160] LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Phosphorylation of TBSMs in LAT
orthologousEvent	[Reaction:R-SSC-202245] Phosphorylation of TBSMs in LAT - Sus scrofa [Reaction:R-BTA-202245] Phosphorylation of TBSMs in LAT - Bos taurus [Reaction:R-CFA-202245] Phosphorylation of TBSMs in LAT - Canis familiaris [Reaction:R-RNO-202245] Phosphorylation of TBSMs in LAT - Rattus norvegicus [Reaction:R-MMU-202245] Phosphorylation of TBSMs in LAT - Mus musculus
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-202364] p-5Y-LAT [plasma membrane]
precedingEvent	[Reaction:R-HSA-202174] Activation of ZAP-70 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202245
summation	[Summation:202326] The adaptor molecule LAT (Linker for the Activation of T cel...
updateTrackers	[UpdateTracker:9788401] Update Tracker - [Reaction:202245] Phosphorylation of TBSMs in LAT - v42:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788401] Update Tracker - [Reaction:202245] Phosphorylation of TBSMs in LAT - v42:[modifyText]
(hasEvent)	[Pathway:R-HSA-202433] Generation of second messenger molecules
(precedingEvent)	[Reaction:R-HSA-202212] Recruitment of PLC-gamma1 to LAT [Reaction:R-HSA-202325] Recruitment of Gads to LAT