Reactome | Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)

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Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) Show undefined attributes

authored	[InstanceEdit:2024092] Jassal, B, 2011-12-14
catalystActivity	[CatalystActivity:1666996] heparanase activity of HPSE dimer [lysosomal lumen]
catalystActivityReference	[CatalystActivityReference:9774585] heparanase activity of HPSE dimer [lysosomal lumen] Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1666994] Jassal, B, 2011-10-14
dbId	1667005
displayName	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
edited	[InstanceEdit:2024092] Jassal, B, 2011-12-14
eventOf	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-1678716] IDUA hydrolyses Heparan sulfate chain(1) - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [DefinedSet:R-HSA-2090050] HS/HPIN-PGs [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1666991] Human heparanase is localized within lysosomes in a stable form [LiteratureReference:1667007] Heterodimer formation is essential for heparanase enzymatic activity [LiteratureReference:9774579] Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence [LiteratureReference:1666987] Human heparanase. Purification, characterization, cloning, and expression
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
orthologousEvent	[Reaction:R-DME-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Drosophila melanogaster [Reaction:R-GGA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Gallus gallus [Reaction:R-XTR-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Xenopus tropicalis [Reaction:R-DRE-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Danio rerio [Reaction:R-SSC-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Sus scrofa [Reaction:R-BTA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Bos taurus [Reaction:R-CFA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Canis familiaris [Reaction:R-RNO-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Rattus norvegicus [Reaction:R-MMU-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Mus musculus
output	[SimpleEntity:R-ALL-2090033] Heparan sulfate chain(1) [lysosomal lumen] [DefinedSet:R-HSA-2090039] HS core proteins [lysosomal lumen]
precedingEvent	[BlackBoxEvent:R-HSA-2024084] HS-GAGs translocate to the lysosome for degradation - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1667005
summation	[Summation:1666979] Heparanase (HPSE) is an endoglycosidase that cleaves heparan...

Referrals

(hasEvent)	[Pathway:R-HSA-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-HSA-1678716] IDUA hydrolyses Heparan sulfate chain(1)