Reactome | HS-GAGs translocate to the lysosome for degradation

HS-GAGs translocate to the lysosome for degradation

Stable Identifier

R-HSA-2024084

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, lysosomal lumen

ReviewStatus

5/5

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HS-GAGs translocate to the lysosome for degradation

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As part of the natural turnover of GAGs, extracellular HSPGs are endocytosed to the lysosome to be degraded (Winchester 2005). Studies of cultured cells suggest that heparanase-2 HPSE2 may block targeting of HPSE and HS-proteoglycan to lysosomes (Levy-Adam et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
15647514	Lysosomal metabolism of glycoproteins Winchester, B	Glycobiology	2005
20576607	Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity Levy-Adam, F, Feld, S, Cohen-Kaplan, V, Shteingauz, A, Gross, M, Arvatz, G, Naroditsky, I, Ilan, N, Doweck, I, Vlodavsky, I	J Biol Chem	2010