HS-GAGs translocate to the lysosome for degradation

Stable Identifier
R-HSA-2024084
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

As part of the natural turnover of GAGs, extracellular KSPGs translocate to the lysosome to be degraded. The translocation process is unsure but could be either endocytosis from outside the cell and/or autophagy from inside the cell (Winchester 2005).

Literature References
PubMed ID Title Journal Year
15647514 Lysosomal metabolism of glycoproteins

Winchester, B

Glycobiology 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created