Reactome | HS-GAGs translocate to the lysosome for degradation

Schema > BlackBoxEvent > Entries

HS-GAGs translocate to the lysosome for degradation Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:161320] lysosomal lumen
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10274918
displayName	HS-GAGs translocate to the lysosome for degradation
eventOf	[Pathway:R-CFA-2024096] HS-GAG degradation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:6597] endocytosis
inferredFrom	[BlackBoxEvent:R-HSA-2024084] HS-GAGs translocate to the lysosome for degradation - Homo sapiens
input	[DefinedSet:R-CFA-2076639] HS/HPIN-PGs [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	HS-GAGs translocate to the lysosome for degradation
output	[DefinedSet:R-CFA-2090050] HS/HPIN-PGs [lysosomal lumen]
precedingEvent	[BlackBoxEvent:R-CFA-2024108] Some HSPGs are secreted to the plasma membrane - Canis familiaris
regulatedBy	[NegativeRegulation:10274919] Negative regulation by 'HPSE2:HS/HPIN-PGs [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-2024084
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-CFA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
(inferredTo)	[BlackBoxEvent:R-HSA-2024084] HS-GAGs translocate to the lysosome for degradation

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