Reactome | (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol

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(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023955] inositol bisdiphosphate tetrakisphosphate diphosphatase activity of NUDT(1) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2023980] Williams, MG, 2011-12-13
dbId	2023973
displayName	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol - Homo sapiens
followingEvent	[Reaction:R-HSA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Homo sapiens [Reaction:R-HSA-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Homo sapiens [Reaction:R-HSA-1855194] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol - Homo sapiens
input	[DefinedSet:R-ALL-2023968] (PP)2-IP4 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889835] An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase [LiteratureReference:1889813] The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein [LiteratureReference:1889932] A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase [LiteratureReference:1889831] Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates [LiteratureReference:1889818] Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family [LiteratureReference:1889819] Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
orthologousEvent	[Reaction:R-DDI-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Dictyostelium discoideum [Reaction:R-SCE-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Saccharomyces cerevisiae [Reaction:R-MMU-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Mus musculus [Reaction:R-RNO-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Rattus norvegicus [Reaction:R-SSC-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Sus scrofa [Reaction:R-CFA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Canis familiaris [Reaction:R-SPO-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Schizosaccharomyces pombe [Reaction:R-CEL-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Caenorhabditis elegans [Reaction:R-DME-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Drosophila melanogaster [Reaction:R-GGA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Gallus gallus [Reaction:R-XTR-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Xenopus tropicalis [Reaction:R-DRE-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Danio rerio [Reaction:R-BTA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Bos taurus
output	[DefinedSet:R-ALL-2023974] 1/3-PP-IP5 [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-1855220] (PP)2-IP4 transports from the nucleus to the cytosol - Homo sapiens [Reaction:R-HSA-1855194] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol - Homo sapiens [Reaction:R-HSA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2023973
summation	[Summation:2023963] Diphosphoinositol polyphosphate phosphohydrolases (DIPP), al...

Referrals

(hasEvent)	[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol
(precedingEvent)	[Reaction:R-HSA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-HSA-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus [Reaction:R-HSA-1855194] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol

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