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Entries
1/3-PP-IP5 transports from the cytosol to the nucleus
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authored
[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity
[CatalystActivity:9954155] narrow pore channel activity of Nuclear Pore Complex (NPC) [nuclear envelope]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:1855226] Williams, MG, 2011-10-28
dbId
1855212
displayName
1/3-PP-IP5 transports from the cytosol to the nucleus
edited
[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf
[Pathway:R-HSA-1855229] IP6 and IP7 transport between cytosol and nucleus - Homo sapiens
followingEvent
[Reaction:R-HSA-1855157] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:160267] import into nucleus
input
[DefinedSet:R-ALL-2023974] 1/3-PP-IP5 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1889803] Identification and characterization of a novel inositol hexakisphosphate kinase
[LiteratureReference:1889868] A conserved family of enzymes that phosphorylate inositol hexakisphosphate
maxDepth
1
modified
[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name
1/3-PP-IP5 transports from the cytosol to the nucleus
orthologousEvent
[Reaction:R-MMU-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Mus musculus
[Reaction:R-RNO-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Rattus norvegicus
[Reaction:R-CFA-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Canis familiaris
[Reaction:R-SPO-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Schizosaccharomyces pombe
[Reaction:R-CEL-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Caenorhabditis elegans
[Reaction:R-DME-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Drosophila melanogaster
[Reaction:R-GGA-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Gallus gallus
[Reaction:R-XTR-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Xenopus tropicalis
[Reaction:R-DRE-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Danio rerio
[Reaction:R-BTA-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Bos taurus
[Reaction:R-SSC-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Sus scrofa
output
[DefinedSet:R-ALL-2023944] 1/3-PP-IP5 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Homo sapiens
[Reaction:R-HSA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2012-12-04
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
[InstanceEdit:9968059] Hill, David P, 2025-10-08
[InstanceEdit:9977084] Hill, David P, 2025-12-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1855212
summation
[Summation:2023995] 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5) and 3-dip...
updateTrackers
[UpdateTracker:9971801] Update Tracker - [Reaction:1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - v95:[addCatalystActivity, modifyText]
[UpdateTracker:9964708] Update Tracker - [Reaction:1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - v94:[removeCatalystActivity]
[UpdateTracker:9984601] Update Tracker - [Reaction:1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - v96:[removeCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9971801] Update Tracker - [Reaction:1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - v95:[addCatalystActivity, modifyText]
[UpdateTracker:9964708] Update Tracker - [Reaction:1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - v94:[removeCatalystActivity]
[UpdateTracker:9984601] Update Tracker - [Reaction:1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - v96:[removeCatalystActivity]
(hasEvent)
[Pathway:R-HSA-1855229] IP6 and IP7 transport between cytosol and nucleus
(precedingEvent)
[Reaction:R-HSA-1855157] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus
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