Reactome | 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol

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5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023999] diphosphoinositol pentakisphosphate kinase activity of PPIP5K1/2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
crossReference	[DatabaseIdentifier:12667483] RHEA:10277
dbId	1855182
displayName	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol - Homo sapiens
followingEvent	[Reaction:R-HSA-1855165] (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol - Homo sapiens [Reaction:R-HSA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-1629765] 5-PP-IP5 [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889794] Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases [LiteratureReference:1889759] Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases [LiteratureReference:1889868] A conserved family of enzymes that phosphorylate inositol hexakisphosphate [LiteratureReference:1889802] Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
orthologousEvent	[Reaction:R-PFA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Plasmodium falciparum [Reaction:R-SCE-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Saccharomyces cerevisiae [Reaction:R-MMU-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Mus musculus [Reaction:R-RNO-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Rattus norvegicus [Reaction:R-CFA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Canis familiaris [Reaction:R-SSC-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Sus scrofa [Reaction:R-SPO-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Schizosaccharomyces pombe [Reaction:R-CEL-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Caenorhabditis elegans [Reaction:R-DME-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Drosophila melanogaster [Reaction:R-GGA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Gallus gallus [Reaction:R-XTR-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Xenopus tropicalis [Reaction:R-BTA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Bos taurus
output	[SimpleEntity:R-ALL-1629732] 1,5-(PP)2-IP4 [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-1855203] 5-PP-IP5 transports from the nucleus to the cytosol - Homo sapiens [Reaction:R-HSA-1855165] (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol - Homo sapiens [Reaction:R-HSA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855182
summation	[Summation:2023993] Inositol hexakisphosphate and diphosphoinositol-pentakisphos...

Referrals

(hasEvent)	[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol
(precedingEvent)	[Reaction:R-HSA-1855165] (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol [Reaction:R-HSA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol

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