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Translocation of PLC-gamma1 to PIP2
Stable Identifier
R-HSA-202354
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Translocation of PLC-gamma1 to PIP2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated PLA-gamma1 translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain.
Literature References
PubMed ID
Title
Journal
Year
11048639
The mechanism of phospholipase C-gamma1 regulation
Suh, PG
,
Kim, MJ
,
Kim, E
,
Ryu, SH
Exp Mol Med
2000
Participants
Input
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(Homo sapiens)
PI(4,5)P2 [plasma membrane]
Output
Activated PLC gamma1 bound to PIP2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Generation of second messenger molecules (Homo sapiens)
Orthologous Events
Translocation of PLC-gamma1 to PIP2 (Bos taurus)
Translocation of PLC-gamma1 to PIP2 (Canis familiaris)
Translocation of PLC-gamma1 to PIP2 (Danio rerio)
Translocation of PLC-gamma1 to PIP2 (Dictyostelium discoideum)
Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)
Translocation of PLC-gamma1 to PIP2 (Gallus gallus)
Translocation of PLC-gamma1 to PIP2 (Mus musculus)
Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)
Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)
Translocation of PLC-gamma1 to PIP2 (Saccharomyces cerevisiae)
Translocation of PLC-gamma1 to PIP2 (Schizosaccharomyces pombe)
Translocation of PLC-gamma1 to PIP2 (Sus scrofa)
Translocation of PLC-gamma1 to PIP2 (Xenopus tropicalis)
Authored
Garapati, P V (2008-01-24)
Rudd, C.E. (2008-01-24)
de Bono, B (2008-01-24)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2007-10-29)
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