Caspase-mediated cleavage of GAS2

Stable Identifier
R-HSA-201639
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase-mediated cleavage of GAS2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cleavage of Gas2 during apoptosis is associated with changes of the microfilament system but does not interfere with its ability to bind F-actin (Brancolini et al., 1995).
Literature References
PubMed ID Title Journal Year
7489707 Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases

Brancolini, C, Benedetti, M, Schneider, C

EMBO J 1995
10564664 Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis

Sgorbissa, A, Benetti, R, Marzinotto, S, Schneider, C, Brancolini, C

J Cell Sci 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3, Caspase-7 [cytosol]

Physical Entity
Caspase-3, Caspase-7 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of GAS2 (Bos taurus)
Caspase-mediated cleavage of GAS2 (Canis familiaris)
Caspase-mediated cleavage of GAS2 (Danio rerio)
Caspase-mediated cleavage of GAS2 (Mus musculus)
Caspase-mediated cleavage of GAS2 (Rattus norvegicus)
Caspase-mediated cleavage of GAS2 (Sus scrofa)
Caspase-mediated cleavage of GAS2 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2007-11-23)
Created
Matthews, L  (2007-09-03)
Cite Us!