Caspase-mediated cleavage of GAS2

Stable Identifier
R-HSA-201639
Type
Reaction
Species
Homo sapiens
Compartment
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Cleavage of Gas2 during apoptosis is associated with changes of the microfilament system but does not interfere with its ability to bind F-actin (Brancolini et al., 1995).

Literature References
PubMed ID Title Journal Year
7489707 Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases

Schneider, C, Brancolini, C, Benedetti, M

EMBO J 1995
10564664 Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis

Marzinotto, S, Benetti, R, Schneider, C, Brancolini, C, Sgorbissa, A

J Cell Sci 1999
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3, Caspase-7 [cytosol]

Orthologous Events
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