Caspase-mediated cleavage of Rock-1

Stable Identifier
R-HSA-201611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase-mediated cleavage of Rock-1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing (Sebbagh et al., 2001). Cleavage and activation of ROCK-1 by caspase-3 plays has also been shown to play a crucial role in in cardiac myocyte apoptosis (Chang et al., 2006).
Literature References
PubMed ID Title Journal Year
16983089 Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis

Chang, J, Xie, M, Shah, VR, Schneider, MD, Entman, ML, Wei, L, Schwartz, RJ

Proc Natl Acad Sci U S A 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of Rock-1 (Bos taurus)
Caspase-mediated cleavage of Rock-1 (Canis familiaris)
Caspase-mediated cleavage of Rock-1 (Drosophila melanogaster)
Caspase-mediated cleavage of Rock-1 (Gallus gallus)
Caspase-mediated cleavage of Rock-1 (Mus musculus)
Caspase-mediated cleavage of Rock-1 (Rattus norvegicus)
Caspase-mediated cleavage of Rock-1 (Sus scrofa)
Caspase-mediated cleavage of Rock-1 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2007-11-23)
Created
Matthews, L  (2007-09-03)
Cite Us!