Reactome | Active ALK recruits PI3K

Active ALK recruits PI3K

Stable Identifier

R-HSA-201515

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Activated ALK in the form of NPM-ALK recruits PI3K. Binding of PI3K to ALK is probably mediated by an adaptor protein that has not yet been identified (Bai et al, 2000; Slupianek et al, 2001; reviewed in Chiarle et al, 2008). Consistent with studies with the NPM-ALK fusion protein, recruitment of PI3K to ALK has also been demonstrated downstream of PTN activation, and phosphorylation of AKT is observed after ALK stimulation with MDK (Stoica et al, 2001; Stoica et al, 2002). In contrast, demonstration of PI3K activation downstream of ALKAL1 or 2 binding has not been demonstrated to date.

Literature References

PubMed ID	Title	Journal	Year
12122009	Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types Stoica, GE, Kuo, AH, Powers, C, Bowden, ET, Sale, EB, Riegel, AT, Wellstein, A	J. Biol. Chem.	2002
11110708	Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway Bai, RY, Ouyang, T, Miething, C, Morris, SW, Peschel, C, Duyster, J	Blood	2000
18097461	The anaplastic lymphoma kinase in the pathogenesis of cancer Chiarle, R, Voena, C, Ambrogio, C, Piva, R, Inghirami, G	Nat. Rev. Cancer	2008
11280786	Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis Slupianek, A, Nieborowska-Skorska, M, Hoser, G, Morrione, A, Majewski, M, Xue, L, Morris, SW, Wasik, MA, Skorski, T	Cancer Res	2001
11278720	Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin Stoica, GE, Kuo, AH, Aigner, A, Sunitha, I, Souttou, B, Malerczyk, C, Caughey, DJ, Wen, D, Karavanov, A, Riegel, AT, Wellstein, A	J Biol Chem	2001