Active ALK recruits PI3K

Stable Identifier
R-HSA-201515
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Activated ALK in the form of NPM-ALK recruits PI3K. Binding of PI3K to ALK is probably mediated by an adaptor protein that has not yet been identified (Bai et al, 2000; Slupianek et al, 2001; reviewed in Chiarle et al, 2008). Consistent with studies with the NPM-ALK fusion protein, recruitment of PI3K to ALK has also been demonstrated downstream of PTN activation, and phosphorylation of AKT is observed after ALK stimulation with MDK (Stoica et al, 2001; Stoica et al, 2002). In contrast, demonstration of PI3K activation downstream of ALKAL1 or 2 binding has not been demonstrated to date.

Literature References
PubMed ID Title Journal Year
12122009 Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types

Wellstein, A, Kuo, AH, Stoica, GE, Riegel, AT, Bowden, ET, Sale, EB, Powers, C

J. Biol. Chem. 2002
11110708 Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway

Ouyang, T, Morris, SW, Bai, RY, Duyster, J, Miething, C, Peschel, C

Blood 2000
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
11280786 Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis

Morrione, A, Xue, L, Hoser, G, Wasik, MA, Slupianek, A, Nieborowska-Skorska, M, Morris, SW, Majewski, M, Skorski, T

Cancer Res 2001
11278720 Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin

Wellstein, A, Caughey, DJ, Kuo, AH, Karavanov, A, Sunitha, I, Malerczyk, C, Aigner, A, Riegel, AT, Souttou, B, Stoica, GE, Wen, D

J Biol Chem 2001
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