Reactome | Active ALK recruits PI3K

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Active ALK recruits PI3K Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10003762
displayName	Active ALK recruits PI3K
eventOf	[Pathway:R-MMU-201556] Signaling by ALK - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-201510] PI3K synthesizes PIP3 downstream of ALK - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-201515] Active ALK recruits PI3K - Homo sapiens
input	[CandidateSet:R-MMU-9850879] Active ALK dimer [plasma membrane] [Complex:R-MMU-74693] PI3K [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active ALK recruits PI3K
output	[Complex:R-MMU-9699995] Active ALK:PI3K [plasma membrane]
precedingEvent	[Reaction:R-MMU-201521] ALK autophosphorylation - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-201515
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-MMU-201510] PI3K synthesizes PIP3 downstream of ALK
(inferredTo)	[BlackBoxEvent:R-HSA-201515] Active ALK recruits PI3K

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