The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

Stable Identifier
R-HSA-201472
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The phosphorylated-r-SMAD1/5/8:Co-SMAD complex rapidly translocates to the nucleus where it binds directly to DNA and interacts with a plethora of transcription co-factors. Regulation of target gene expression can be either positive or negative. A classic example of a target gene of the pathway are the genes encoding for i-SMADs. Thus, BMP2/SMAD signalling induces the expression of the negative regulators of the pathway (a negative feedback loop).

Literature References
PubMed ID Title Journal Year
12592392 An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity

Xiao, Z, Latek, R, Lodish, HF

Oncogene 2003
12821673 A novel nuclear export signal in Smad1 is essential for its signaling activity

Xiao, Z, Brownawell, AM, Macara, IG, Lodish, HF

J Biol Chem 2003
11509558 Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

Xiao, Z, Watson, N, Rodriguez, C, Lodish, HF

J Biol Chem 2001
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created