Reactome | The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

Stable Identifier

R-HSA-201472

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

ReviewStatus

5/5

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The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

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The phosphorylated-r-SMAD1/5/8:Co-SMAD complex rapidly translocates to the nucleus where it binds directly to DNA and interacts with a plethora of transcription co-factors. Regulation of target gene expression can be either positive or negative. A classic example of a target gene of the pathway are the genes encoding for i-SMADs. Thus, BMP2/SMAD signalling induces the expression of the negative regulators of the pathway (a negative feedback loop).

Literature References

PubMed ID	Title	Journal	Year
12821673	A novel nuclear export signal in Smad1 is essential for its signaling activity Xiao, Z, Brownawell, AM, Macara, IG, Lodish, HF	J Biol Chem	2003
12592392	An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity Xiao, Z, Latek, R, Lodish, HF	Oncogene	2003
11509558	Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals Xiao, Z, Watson, N, Rodriguez, C, Lodish, HF	J Biol Chem	2001