Reactome | The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

Stable Identifier

R-HSA-201472

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

ReviewStatus

5/5

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The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

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The phosphorylated-r-SMAD1/5/8:Co-SMAD complex rapidly translocates to the nucleus where it binds directly to DNA and interacts with a plethora of transcription co-factors. Regulation of target gene expression can be either positive or negative. A classic example of a target gene of the pathway are the genes encoding for i-SMADs. Thus, BMP2/SMAD signalling induces the expression of the negative regulators of the pathway (a negative feedback loop).

Literature References

PubMed ID	Title	Journal	Year
12821673	A novel nuclear export signal in Smad1 is essential for its signaling activity Macara, IG, Lodish, HF, Brownawell, AM, Xiao, Z	J Biol Chem	2003
12592392	An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity Lodish, HF, Latek, R, Xiao, Z	Oncogene	2003
11509558	Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals Lodish, HF, Rodriguez, C, Watson, N, Xiao, Z	J Biol Chem	2001