Reactome | Phospho-R-Smad1/5/8 forms a complex with Co-Smad

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Phospho-R-Smad1/5/8 forms a complex with Co-Smad Show undefined attributes

authored	[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
dbId	201422
displayName	Phospho-R-Smad1/5/8 forms a complex with Co-Smad
eventOf	[Pathway:R-HSA-201451] Signaling by BMP - Homo sapiens
followingEvent	[Reaction:R-HSA-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Homo sapiens
input	2 × [DefinedSet:R-HSA-201482] p-2S-SMAD1/5/8 [cytosol] [EntityWithAccessionedSequence:R-HSA-170862] SMAD4 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202645] Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways [LiteratureReference:202606] Structural basis of Smad1 activation by receptor kinase phosphorylation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phospho-R-Smad1/5/8 forms a complex with Co-Smad
orthologousEvent	[Reaction:R-CFA-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Canis familiaris [Reaction:R-CEL-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Caenorhabditis elegans [Reaction:R-DME-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Drosophila melanogaster [Reaction:R-GGA-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Gallus gallus [Reaction:R-XTR-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Xenopus tropicalis [Reaction:R-SSC-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Sus scrofa [Reaction:R-BTA-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Bos taurus [Reaction:R-RNO-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Rattus norvegicus [Reaction:R-MMU-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Mus musculus
output	[Complex:R-HSA-201419] p-2S-SMAD1/5/8:SMAD4 [cytosol]
precedingEvent	[Reaction:R-HSA-201453] Phospho-R-Smad1/5/8 dissociates from the receptor complex - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:203122] Heldin, CH, 2007-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-201422
summation	[Summation:176014] The phosphorylated C-terminal tail of R-SMAD induces a confo...
updateTrackers	[UpdateTracker:9788657] Update Tracker - [Reaction:201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - v41:[modifyText] [UpdateTracker:9787926] Update Tracker - [Reaction:201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - v44:[modifyText] [UpdateTracker:9775701] Update Tracker - [Reaction:201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - v78:[modifyText] [UpdateTracker:9789512] Update Tracker - [Reaction:201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788657] Update Tracker - [Reaction:201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - v41:[modifyText] [UpdateTracker:9787926] Update Tracker - [Reaction:201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - v44:[modifyText] [UpdateTracker:9775701] Update Tracker - [Reaction:201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - v78:[modifyText] [UpdateTracker:9789512] Update Tracker - [Reaction:201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - v38:[modifyText]
(hasEvent)	[Pathway:R-HSA-201451] Signaling by BMP
(precedingEvent)	[Reaction:R-HSA-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

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