Reactome | MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG

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MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG Show undefined attributes

catalystActivity	[CatalystActivity:10665320] formate-tetrahydrofolate ligase activity of MTHFD1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10665322
displayName	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG
eventOf	[Pathway:R-XTR-196757] Metabolism of folate and pterines - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG - Xenopus tropicalis [Reaction:R-XTR-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] [SimpleEntity:R-ALL-197969] THFPG [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate
output	[SimpleEntity:R-ALL-111353] 10-formyl-THFPG [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-XTR-197958] FPGS-2 transforms THF to THFPG - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-200711
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-XTR-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG [Reaction:R-XTR-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG
(inferredTo)	[Reaction:R-HSA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG

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