The formate-tetrahydrofolate ligase activity of the trifunct...

created [InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
dbId 200688
displayName The formate-tetrahydrofolate ligase activity of the trifunct...
modified [InstanceEdit:201090] D'Eustachio, P, 2007-07-30 19:06:17
schemaClass Summation
text The formate-tetrahydrofolate ligase activity of the trifunctional MTHFD1 enzyme catalyzes the reaction of THF polyglutamate, formate, and ATP to form 10-formylTHF polyglutamate, ADP, and orthophosphate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).
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