Reactome | AKT can phosphorylate NR4A1 (NUR77)

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AKT can phosphorylate NR4A1 (NUR77) Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:199274] protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:199866] Jassal, B, 2007-07-12 14:41:47
dbId	199863
diseaseReaction	[Reaction:R-HSA-2399988] AKT1 E17K mutant phosphorylates NR4A1 (NUR77) - Homo sapiens
displayName	AKT can phosphorylate NR4A1 (NUR77)
eventOf	[Pathway:R-HSA-198693] AKT phosphorylates targets in the nucleus - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-199831] NR4A1 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199827] Akt phosphorylates and regulates the orphan nuclear receptor Nur77
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	AKT can phosphorylate NR4A1 (NUR77)
orthologousEvent	[Reaction:R-CEL-199863] AKT can phosphorylate NR4A1 (NUR77) - Caenorhabditis elegans [Reaction:R-DME-199863] AKT can phosphorylate NR4A1 (NUR77) - Drosophila melanogaster [Reaction:R-GGA-199863] AKT can phosphorylate NR4A1 (NUR77) - Gallus gallus [Reaction:R-DRE-199863] AKT can phosphorylate NR4A1 (NUR77) - Danio rerio [Reaction:R-RNO-199863] AKT can phosphorylate NR4A1 (NUR77) - Rattus norvegicus [Reaction:R-MMU-199863] AKT can phosphorylate NR4A1 (NUR77) - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-199846] p-S351-NR4A1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-198298] AKT translocates to the nucleus - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-199863
summation	[Summation:199824] AKT inhibits DNA binding of NUR77 and inhibits its pro-apopt...
updateTrackers	[UpdateTracker:9789245] Update Tracker - [Reaction:199863] AKT can phosphorylate NR4A1 (NUR77) - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789245] Update Tracker - [Reaction:199863] AKT can phosphorylate NR4A1 (NUR77) - v38:[modifyText]
(normalReaction)	[Reaction:R-HSA-2399988] AKT1 E17K mutant phosphorylates NR4A1 (NUR77)
(hasEvent)	[Pathway:R-HSA-198693] AKT phosphorylates targets in the nucleus

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