Reactome | Negative regulation of the PI3K/AKT network

Schema > Pathway > Entries

created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11078947
displayName	Negative regulation of the PI3K/AKT network
eventOf	[Pathway:R-SPO-1257604] PIP3 activates AKT signaling - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SPO-199425] PHLPP dephosphorylates S473 in AKT - Schizosaccharomyces pombe [Pathway:R-SPO-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-199418] Negative regulation of the PI3K/AKT network - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Negative regulation of the PI3K/AKT network
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-199418
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SPO-1257604] PIP3 activates AKT signaling
(inferredTo)	[Pathway:R-HSA-199418] Negative regulation of the PI3K/AKT network

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