Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Schema > Pathway > Entries

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Show undefined attributes

authored	[InstanceEdit:198923] de Bono, B, 2007-07-08 12:58:15 [InstanceEdit:5685601] Garapati, Phani Vijay, 2015-03-27
created	[InstanceEdit:198934] de Bono, B, 2007-07-08 13:23:45
dbId	198933
displayName	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
doi	10.3180/r-hsa-198933.2
eventOf	[Pathway:R-HSA-1280218] Adaptive Immune System - Homo sapiens
figure	[Figure:199175] /figures/immune_synapse_figure_1.jpg
goBiologicalProcess	[GO_BiologicalProcess:159969] regulation of immune response
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-198941] VCAM1 binds Integrin alpha4beta1 - Homo sapiens [Reaction:R-HSA-9679740] ITGA4:ITGB1 binds natalizumab - Homo sapiens [Reaction:R-HSA-198955] TCR complex interacts with peptide antigen-presenting MHC Class I - Homo sapiens [Reaction:R-HSA-198958] KIR2DL2/3 interacting with HLA-C group 1 (Cw4) - Homo sapiens [Reaction:R-HSA-198983] NKG2D homodimer interacting with ligands - Homo sapiens [Reaction:R-HSA-199014] CD96 binds PVR - Homo sapiens [Reaction:R-HSA-199032] MADCAM1-1 binds Integrin alpha4beta7 - Homo sapiens [Reaction:R-HSA-199043] LILRs interact with MHC Class I - Homo sapiens [Reaction:R-HSA-199046] Ligands bind L-selectin - Homo sapiens [Reaction:R-HSA-199050] ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) - Homo sapiens [Reaction:R-HSA-199062] KLRC1:KLRD1 heterodimer interacts with HLA-E - Homo sapiens [Reaction:R-HSA-199079] Epithelial cadherin binds to KLRG1 - Homo sapiens [Reaction:R-HSA-199112] CRTAM binds to NECL2 - Homo sapiens [Reaction:R-HSA-199131] PVR binds CD226 - Homo sapiens [Reaction:R-HSA-199144] Nectin 2 binds CD226 - Homo sapiens [Reaction:R-HSA-199154] CD200 binds to CD200R - Homo sapiens [Reaction:R-HSA-199169] MHC Class I interacts with CD160 - Homo sapiens [Reaction:R-HSA-199161] Fc gamma receptors interact with antigen-bound IgG - Homo sapiens [Reaction:R-HSA-199404] CD40L binds CD40 - Homo sapiens [Reaction:R-HSA-199093] CXADR binds to AMICA1 - Homo sapiens [Reaction:R-HSA-199518] C3d-complexed antigen binds to complement receptor - Homo sapiens [Reaction:R-HSA-199558] KIR2DL1 interacting with HLA-C group 2 (Cw3) - Homo sapiens [Reaction:R-HSA-199566] KIR3DL1 interacting with HLA Bw4 - Homo sapiens [Reaction:R-HSA-199576] KIR3DL2 interacting with HLA-A3 - Homo sapiens [Reaction:R-HSA-199579] KIR2DL4 interacting with HLA-G - Homo sapiens [Reaction:R-HSA-199587] KIR2DS1 interacting with HLA-C group 2 (Cw4) - Homo sapiens [Reaction:R-HSA-199583] KIR2DS2 interacting with HLA-C group 1 (Cw3) - Homo sapiens [Reaction:R-HSA-5685606] CLEC2D binds KLRB1 - Homo sapiens [Reaction:R-HSA-5685607] Sialic acid binds SIGLEC - Homo sapiens [Reaction:R-HSA-5685600] viral HA binds NCRI - Homo sapiens [Reaction:R-HSA-5685602] NCR3LG1 binds NCR3 - Homo sapiens [Reaction:R-HSA-6793275] CMVPP65 binds NCR3 - Homo sapiens [Reaction:R-HSA-5685608] CLEC2B binds KLRF1 dimer - Homo sapiens [Reaction:R-HSA-5685604] SLAMF6 binds SLAMF6 - Homo sapiens [Reaction:R-HSA-5685603] SAP and EAT2 binds SLAMF6 - Homo sapiens [Reaction:R-HSA-5685605] SLAMF7 binds SLAMF7 - Homo sapiens [Reaction:R-HSA-5686625] LAIR1 binds collagen - Homo sapiens [Reaction:R-HSA-5696356] OSCAR binds collagen and SP-D - Homo sapiens [Reaction:R-HSA-5696357] LAIR2 binds collagen - Homo sapiens [Reaction:R-HSA-5696358] TREM,CD300 binds lipids - Homo sapiens [Reaction:R-HSA-8850356] TCR binds microbial lipid-based antigen via CD1 - Homo sapiens [Reaction:R-HSA-8850326] TCR binds self-lipid-based antigen via CD1 - Homo sapiens [Reaction:R-HSA-8862090] PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G - Homo sapiens [Reaction:R-HSA-8862084] PILRA,PILRB bind CD99 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-09-24
literatureReference	[LiteratureReference:200298] B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands [LiteratureReference:200306] Immune synapses in T-cell activation [LiteratureReference:200314] Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses [LiteratureReference:200299] The immunological synapse [LiteratureReference:5687338] Functions of natural killer cells [LiteratureReference:5690953] Comparative genomics of natural killer cell receptor gene clusters
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
orthologousEvent	[Pathway:R-CEL-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Caenorhabditis elegans [Pathway:R-DME-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Drosophila melanogaster [Pathway:R-GGA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Gallus gallus [Pathway:R-XTR-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Xenopus tropicalis [Pathway:R-DRE-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Danio rerio [Pathway:R-SSC-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Sus scrofa [Pathway:R-BTA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Bos taurus [Pathway:R-CFA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Canis familiaris [Pathway:R-RNO-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Rattus norvegicus [Pathway:R-MMU-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Mus musculus
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201344] Trowsdale, J, 2007-08-06 [InstanceEdit:5692843] Barrow, Alexander D, 2015-05-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-198933
summation	[Summation:200289] A number of receptors and cell adhesion molecules play a key...
updateTrackers	[UpdateTracker:9787387] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v45:[updateContainedRLE] [UpdateTracker:9781757] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v60:[addHasEvent] [UpdateTracker:9784078] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v54:[addHasEvent, updateContainedRLE] [UpdateTracker:9779745] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v64:[updateContainedRLE] [UpdateTracker:9784766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v53:[addHasEvent, addLiteratureReference] [UpdateTracker:9789444] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v38:[addLiteratureReference, updateContainedRLE] [UpdateTracker:9788612] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v41:[updateContainedRLE] [UpdateTracker:9784909] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v52:[updateContainedRLE] [UpdateTracker:9792166] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v23:[updateContainedRLE] [UpdateTracker:9787970] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v44:[updateContainedRLE] [UpdateTracker:9776766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9783561] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v56:[addHasEvent, updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-1280218] Adaptive Immune System

(updatedInstance)

[UpdateTracker:9787387] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v45:[updateContainedRLE]
[UpdateTracker:9781757] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v60:[addHasEvent]
[UpdateTracker:9784078] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v54:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779745] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v64:[updateContainedRLE]
[UpdateTracker:9784766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v53:[addHasEvent, addLiteratureReference]
[UpdateTracker:9789444] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v38:[addLiteratureReference, updateContainedRLE]
[UpdateTracker:9788612] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v41:[updateContainedRLE]
[UpdateTracker:9784909] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v52:[updateContainedRLE]
[UpdateTracker:9792166] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v23:[updateContainedRLE]
[UpdateTracker:9787970] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v44:[updateContainedRLE]
[UpdateTracker:9776766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9783561] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v56:[addHasEvent, updateContainedRLE]

Cite Us!