Reactome | CD40L binds CD40

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CD40L binds CD40 Show undefined attributes

authored	[InstanceEdit:198923] de Bono, B, 2007-07-08 12:58:15
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:199403] de Bono, B, 2007-07-10 10:04:38
dbId	199404
displayName	CD40L binds CD40
entityOnOtherCell	[Complex:R-HSA-5672851] CD40LG trimer [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-5676594] TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway - Homo sapiens [Pathway:R-HSA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Homo sapiens
followingEvent	[Reaction:R-HSA-5676597] TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 - Homo sapiens
input	[Complex:R-HSA-5672850] CD40 trimer [plasma membrane] [Complex:R-HSA-5672851] CD40LG trimer [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199407] CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CD40L binds CD40
orthologousEvent	[Reaction:R-GGA-199404] CD40L binds CD40 - Gallus gallus [Reaction:R-XTR-199404] CD40L binds CD40 - Xenopus tropicalis [Reaction:R-DRE-199404] CD40L binds CD40 - Danio rerio [Reaction:R-SSC-199404] CD40L binds CD40 - Sus scrofa [Reaction:R-BTA-199404] CD40L binds CD40 - Bos taurus [Reaction:R-CFA-199404] CD40L binds CD40 - Canis familiaris [Reaction:R-RNO-199404] CD40L binds CD40 - Rattus norvegicus [Reaction:R-MMU-199404] CD40L binds CD40 - Mus musculus
output	[Complex:R-HSA-199402] CD40:CD40L trimer [plasma membrane]
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201344] Trowsdale, J, 2007-08-06 [InstanceEdit:5692843] Barrow, Alexander D, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-199404
summation	[Summation:199411] CD40 is a member of the Tumour Necrosis Factor receptor fami...
updateTrackers	[UpdateTracker:9785429] Update Tracker - [Reaction:199404] CD40L binds CD40 - v52:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9785429] Update Tracker - [Reaction:199404] CD40L binds CD40 - v52:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell [Pathway:R-HSA-5676594] TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
(precedingEvent)	[Reaction:R-HSA-5676597] TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40